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观察正常人、肝硬化患者综合治疗前后血浆内皮素含量变化。结果肝硬化患者血浆内皮素含量为（６４．３±１５．３）ｎｇ／Ｌ，显著高于正常人（４２．５±７．４）ｎｇ／Ｌ，Ｐ＜０．０１；肝硬化伴腹水患者为（７５．５±９．５）ｎｇ／Ｌ，高于无腹水患者（５４．１±１２．１）ｎｇ／Ｌ。肝硬化患者经综合治疗１月后，伴或无腹水组分别为（７０．５±１０．０）和（５２．８±１３．１）ｎｇ／Ｌ，与同组治疗前比较无显著差异。提示血浆内皮素与肝硬化腹水形成的病理生理过程有关；一般内科治疗不能显著降低血浆内皮素水平。
To observe the changes of plasma endothelin levels in patients with cirrhosis before and after the comprehensive treatment. Results The level of plasma endothelin in cirrhotic patients was (64.3 ± 15.3) ng / L, significantly higher than that in normal controls (42.5 ± 7.4) ng / L, P <0.01; cirrhosis with ascites The patients were (75.5 ± 9.5) ng / L higher than those without ascites (54.1 ± 12.1) ng / L. After one month of comprehensive treatment, the patients with cirrhosis were (70.5 ± 10.0) and (52.8 ± 13.1) ng / L with or without ascites, respectively. There was no significant difference between the two groups before treatment. Tip plasma endothelin and cirrhosis of the formation of ascites pathophysiological processes; general medical treatment can not significantly reduce plasma endothelin levels.