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5. Systems pharmacology modeling in neuroscience: Prediction and outcome of PF-04995274, a 5-HT4 partia

Systems pharmacology modeling in neuroscience: Prediction and outcome of PF-04995274, a 5-HT4 partia

来源 :阿尔茨海默氏病研究进展(英文) | 被引量 : 0次 | 上传用户：guoguo1guoguo1

【摘 要】

：

Background: 5-HT4receptors in cortex and hippocampus area are considered as a possible target for modulation of cognitive functions in Alzheimer’s disease (AD)

【作 者】

：

Timothy Nicholas Sridhar Duvvu 

【机 构】

：

ICON,InSilicoBiosciences,PfizerGlobalResearchandDevelopment

【出 处】

：

阿尔茨海默氏病研究进展(英文)

【发表日期】

：

2013年3期

【关键词】

：

SYSTEMS PHARMACOLOGY 5-HT4 Receptor Partial AGONIST Scopolamine-Reversal Systems 

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Background: 5-HT4receptors in cortex and hippocampus area are considered as a possible target for modulation of cognitive functions in Alzheimer’s disease (AD). A systems pharmacology approach was adopted to evaluate the potential of the 5-HT4 modulation

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