论文部分内容阅读
已发现吲哚类化合物,特别是苯并噻唑类化合物有很强的杀丝虫成虫和微丝蚴的作用,为了进一步探讨吲哚类化合物对各发育期丝虫的作用,观察了苯并噻唑类化合物对魏氏丝虫、马来丝虫和彭亨丝虫的第三期幼虫及成虫前期的疗效。多乳鼠自皮下接种魏氏丝虫、马来丝虫和彭亨丝虫的第三期幼虫,虫数分别为50,70和85条,试用的药物为5种5-甲基-苯并噻唑类衍生物及其5-甲氧基类似物。动物于感染后3d口服单剂药物,以观察其对第三期幼虫的作用,或感染后28,38和32d给药,以观察药物分别对魏氏丝虫、马来丝虫
It has been found that indoles, especially benzothiazoles, have a strong role in killing filariasis adults and microfilariae. In order to further investigate the effects of indoles on filarial developmental stages, benzothiazoles The Efficacy of Compounds on the Third Period Larvae and Adults of Wilitons, Malayan Worm and Penaeid Worm. The third instar larvae of Wieliczia, Malayan filariasis and Penaeid silkworm were inoculated subcutaneously with more than 50, 70 and 85 insects respectively. The tested drugs were 5 kinds of 5-methyl-benzothiazoles Derivatives and their 5-methoxy analogues. The animals were orally given a single dose of the drug 3 days after the infection to observe its effect on the third larvae or to be administered at 28, 38 and 32 days after the infection to observe the effects of the drugs on Wilitis,