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本文应用免疫组化方法,观察70例乳腺癌c—erbB—2癌基因和ER、PR的表达情况。发现c—erbB—2阳性表达率为60%,其中浸润性导管癌阳性率为最高(75.0%)。其表达与肿瘤大小、淋巴结转移情况呈正相关。ER、PR表达与肿瘤体积有相关性,与组织学类型和淋巴结转移无明显相关性。因而c—erbB—2表达与ER、PR表达之间可能互有影响,从而影响乳腺癌的生物学行为。提示c—erbB—2对治疗方案的选择有一定的应用价值。
In this paper, immunohistochemistry was used to observe the expression of c-erbB-2 oncogene, ER and PR in 70 cases of breast cancer. The positive rate of c-erbB-2 expression was found to be 60%, with the highest positive rate of invasive ductal carcinoma (75.0%). Its expression was positively correlated with tumor size and lymph node metastasis. There was a correlation between the expression of ER and PR and tumor volume, and no correlation with histological type and lymph node metastasis. Therefore, c-erbB-2 expression and ER, PR expression may have mutual influence, thus affecting the biological behavior of breast cancer. Tips c-erbB-2 has a certain application value for the choice of treatment plan.