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目的研究乳腺癌组织中p53蛋白的表达,探讨其表达结果与临床病理学指标的关系。方法以120例经病理医师确诊为乳腺癌的活性标本为研究对象,术前均未做任何放疗和化疗,诊断明确,临床资料完整,所有患者均行乳腺癌改良根治术,Ⅰ期51例,Ⅱ期41例,Ⅲ期28例;肿瘤直径1～10cm,<2cm者31例,≥2cm者89例;有腋窝淋巴结转移63例,无淋巴结转移57例。应用免疫组织化学SP法检测乳腺癌活性标本中p53的表达。结果 120例乳腺癌中,p53蛋白的阳性表达率为80.0%(96/120),其表达在乳腺癌不同临床分期、有无淋巴结转移上有显著差异(P均<0.05),而不同肿瘤大小其p53蛋白表达水平差异无统计学意义(P>0.05)。结论 p53蛋白表达与乳腺癌转移有关,是乳腺癌患者预后差的指标,检测p53对乳腺癌患者的预后判断和治疗有指导价值。
Objective To study the expression of p53 protein in breast cancer and to explore its relationship with the clinicopathological parameters. Methods A total of 120 active specimens diagnosed as breast cancer by pathologists were included in this study. All the patients had no radiotherapy and chemotherapy before operation. The diagnosis was clear and the clinical data were complete. All patients underwent radical mastectomy for breast cancer. Fifty-one patients were stage Ⅰ, There were 41 cases of stage Ⅱ and 28 cases of stage Ⅲ. There were 31 cases with tumor size of 1 ~ 10cm, <2cm and 89 cases ≥2cm. There were 63 cases with axillary lymph node metastasis and 57 cases without lymph node metastasis. Immunohistochemical SP method was used to detect the expression of p53 in the active specimens of breast cancer. Results The positive rate of p53 protein was 80.0% (96/120) in 120 cases of breast cancer. The expression of p53 protein was significantly different in different clinical stage and lymph node metastasis (all P <0.05), but different tumor size The expression of p53 protein showed no significant difference (P> 0.05). Conclusion The expression of p53 protein is related to the metastasis of breast cancer, which is a poor prognostic factor in patients with breast cancer. Detection of p53 has guiding value in the prognosis and treatment of patients with breast cancer.