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目的:研究A型GABA受体α1亚型(GABRA1)在癫痫患者病灶额叶脑组织中的表达变化与癫痫发病机制的关系.方法采用TaqMan探针荧光定量PCR检测GABRA1在癫痫患者病灶额叶脑组织及对照组额叶脑组织中的表达量的差异.结果对照组及癫痫患者额叶GABRA1平均相对表达强度为3.785±1.444和4.399±2.89,两者间无显著差异(P>0.05).结论额叶脑组织中GABAA受体与癫痫的发生没有相关性.
Objective: To investigate the relationship between the expression of GABA1 subtype A (GABRA1) and the pathogenesis of epilepsy in patients with epilepsy.Methods TaqMan probe was used to detect the expression of GABRA1 in the frontal lobe of the epileptic patients And control group.Results The average relative expression intensity of frontal lobe GABRA1 in control group and epileptic patients was 3.785 ± 1.444 and 4.399 ± 2.89, there was no significant difference between the two groups (P> 0.05) .Conclusion There is no correlation between GABAA receptor and the occurrence of epilepsy in the frontal lobe.