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目的探讨尤瑞克林联合曲克芦丁对急性脑梗死患者p选择素、D-二聚体、血管性血友病因子(v WF)的影响及神经功能改善的作用。方法选取我院2013年1月-2015年1月收治的107例确诊为急性脑梗死患者的患者,将其随机分为对照组53例与观察组54例。对照组给予曲克芦丁治疗,观察组在对照组的基础上给予尤瑞克林治疗。观察两组患者治疗前后P选择素、D-二聚体、v WF及神经功能改善情况。结果观察组总有效率为96.30%,明显高于对照组的总有效率69.81%,差异有统计学意义(P<0.05);治疗后21 d,观察组神经功能比对照组均明显改善(P<0.05);治疗后两组P选择素、D-二聚体、v WF均有改善,观察组明显较对照组小(P<0.05)。结论尤瑞克林与曲克芦丁联合使用可发挥协同作用,影响脑梗死患者颅内血管、血小板功能,明显改善患者神经功能,无明显不良反应,值得临床广泛使用。
Objective To investigate the effect of uracil combined with troxerutin on p-selectin, D-dimer and von Willebrand factor (vWF) in patients with acute cerebral infarction and to improve the neurological function. Methods A total of 107 patients with acute cerebral infarction who were admitted to our hospital from January 2013 to January 2015 were randomly divided into control group (n = 53) and observation group (n = 54). The control group was treated with troxerutin, and the observation group was treated with urelin based on the control group. The changes of P-selectin, D-dimer, v WF and neurological function before and after treatment in both groups were observed. Results The total effective rate in observation group was 96.30%, significantly higher than that in control group (69.81%), the difference was statistically significant (P <0.05); on the 21st day after treatment, the neurological function in observation group was significantly improved than that in control group <0.05). After treatment, P-selectin, D-dimer and v WF were improved in both groups. The observation group was significantly smaller than the control group (P <0.05). Conclusion The combination of uracil and troxerutin can exert a synergistic effect on intracranial vascular and platelet function in patients with cerebral infarction, and significantly improve the neurological function of patients without obvious adverse reactions, which is worth widely used in clinic.