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利用生长因子受体靶向传递重组生长因子外毒素融合蛋白特异性地杀伤肿瘤细胞是肿瘤靶向治疗的最新突破。业已表明急性粒细胞白血病异常高地表达IL_6R、GM-CSF_R和IL_3R,在白血病异常造血调控中发挥重要作用,因此可充分利用这些高表达的受体作为靶子,选择性地与重组IL_6-PE_(40)、IL_3-pE_(40)和GM-CSF-PF_(40)假单胞菌外毒素融蛋白结合,达到有的放矢的治疗白血病。在这些受体中,IL_6R显得特别重要,因为它仅表达于人的
Targeted delivery of recombinant growth factor exotoxin fusion proteins using growth factor receptors specifically kill tumor cells is the latest breakthrough in targeted cancer therapy. It has been shown that abnormal expression of IL-6R, GM-CSF_R and IL_3R in acute myeloid leukemia plays an important role in the regulation of abnormal hematopoiesis in leukemias, and therefore, these highly expressed receptors can be fully utilized as targets to selectively interact with recombinant IL_6-PE_ (40 ), IL_3-pE_ (40) and GM-CSF-PF_ (40) Pseudomonas exotoxin fusion protein, to achieve the targeted treatment of leukemia. Among these receptors, IL-6R is of particular importance as it is expressed only in humans