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目的:探讨三维适形放疗联合替莫唑胺(TMZ)治疗成人恶性脑胶质细胞瘤术后患者的疗效和安全性。方法:29例成人恶性脑胶质细胞瘤术后患者随机分为观察组(15例)和对照组(14例),分别接受三维适形放疗联合TMZ治疗和单纯三维适形放疗。观察并比较两组的疗效、生存率和不良反应发生情况。结果:观察组的有效率为53.3%,高于对照组的28.6%,但组间比较差异无统计学意义,P>0.05。观察组1年生存率为80.0%,虽然高于对照组的71.4%,但组间比较差异无统计学意义,P>0.05;2年生存率为66.7%,显著高于对照组的28.6%,组间比较差异有统计学意义,P<0.05。两组均未发生严重不良反应且不良反应发生率组间比较差异无统计学意义,P>0.05。结论:三维适形放疗联合TMZ治疗恶性脑胶质细胞瘤术后患者疗效优于局部单纯放疗,且不良反应轻微,值得临床推广应用。
Objective: To investigate the efficacy and safety of three-dimensional conformal radiotherapy combined with temozolomide (TMZ) in the treatment of adult malignant glioma after surgery. Methods: Twenty-nine patients with adult malignant glioma were randomly divided into observation group (n = 15) and control group (n = 14). Three-dimensional conformal radiotherapy combined with TMZ and three-dimensional conformal radiotherapy were performed respectively. The curative effect, survival rate and adverse reactions of the two groups were observed and compared. Results: The effective rate of the observation group was 53.3%, higher than that of the control group (28.6%), but there was no significant difference between the two groups (P> 0.05). The 1-year survival rate in the observation group was 80.0%, which was higher than 71.4% in the control group, but there was no significant difference between the two groups (P> 0.05). The 2-year survival rate was 66.7%, significantly higher than that in the control group (28.6% The difference between the groups was statistically significant, P <0.05. No serious adverse reactions occurred in both groups and the incidence of adverse reactions was no significant difference between the two groups, P> 0.05. Conclusion: Three-dimensional conformal radiotherapy combined with TMZ in patients with malignant glioma after surgery is superior to local radiotherapy alone, and mild side effects, it is worthy of clinical promotion and application.