采用小鼠Ｓ１８０模型，对比研究局部电热针热疗联合局部卡铂化疗、单纯热疗及单纯化疗的抑瘤作用，同时于实验后即刻、６小时、２４小时、７２小时、１０天分别处死动物，对光学及电子显微镜下肿瘤的形态学变化进行观察。结果显示，局部电热针热疗同时联合局部卡铂化疗对小鼠Ｓ１８０的治疗效果远远大于其他各组，统计学上有显著差异（Ｐ＜０．０５）。 A mouse S180 model was used to compare the anti-tumor effects of local electrothermal needle hyperthermia combined with localized carboplatin chemotherapy, hyperthermia alone, and chemotherapy alone. At the same time, the animals were sacrificed immediately, 6 hours, 24 hours, 72 hours, and 10 days after the experiment. The observation of the morphological changes of the tumor under optical and electron microscopes. The results showed that the effect of local electrothermal needle hyperthermia combined with local carboplatin chemotherapy on mouse S180 was far greater than other groups, with statistically significant differences (P<0.05).