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Pharmaceutical wastewater treatment plants (WWTPs) are thought to be a seedbed and reservoirs for multi-antibiotic resistant pathogenic bacteria which can be transmitted to the air environment through aeration.We quantified airbe multi-antibiotic resistance in a full-scale plant to treat antibiotics-producing wastewater by collecting bioaerosol samples from December 2014 to July 2015.Gram-negative opportunistic pathogenic bacteria (GNOPB) were isolated,and antibiotic susceptibility tests against 18 commonly used antibiotics,including 11 β-lactam antibiotics,3 aminoglycosides,2 fluoroquinolones,1 furan and 1 sulfonamide,were conducted.More than 45％ of airbe bacteria isolated from the pharmaceutical WWTP were resistant to three or more antibiotics,and some opportunistic pathogenic strains were resistant to 16 antibiotics,whereas 45.3％ and 50.3％ of the strains isolated from residential community and municipal WWTP showed resistance to three or more antibiotics.The calculation of the multiple antibiotic resistance (MAR) index demonstrated that the air environment in the pharmaceutical WWTP was highly impacted by antibiotic resistance,while the residential community and municipal WWTP was less impacted by antibiotic resistance.In addition,we determined that the dominant genera of opportunistic pathogenic bacteria isolated from all bioaerosol samples were Adnetobacter,Alcaligenes,Citrobacter,Enterobacter,Escherichia,Klebsiella,Pantoea,Pseudomonas and Sphingomonas.Collectively,these results indicate the proliferations and spread of antibiotic resistance through bioaerosols in WWTP treating cephalosporin-producing wastewater,which imposed a potential health risk for the staff and residents in the neighborhood,calling for administrative measures to minimize the air-transmission hazard.