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目的:分析尿碘浓度(UIC)在不同危险度分层的分化型甲状腺癌(DTC)患者中与n 131I治疗效果的关系。n 方法:选取2018年1月至2019年2月在天津医科大学总医院接受首次n 131I治疗的DTC患者181例[男75例，女106例，年龄(44.1±12.5)岁]进行回顾性分析。将患者分为中低危组和高危组，n 131I疗效分为疗效满意(ER)和疗效不满意(non-ER)，评价指标包括性别、年龄、治疗前刺激性甲状腺球蛋白(ps-Tg)、UIC等。采用Mann-Whitney n U检验进行组间UIC差异比较；采用logistic回归分析疗效影响因素。n 结果:181例患者中113例为中低危患者，UIC为111.60(55.80, 204.65) μg/L；ps-Tg为2.08(0.63, 4.91) μg/L。中低危患者中，和ER组(86例)比较，non-ER组(27例)有较高的UIC和ps-Tg水平(n z值：-2.585、-4.511,均n P<0.05)。68例高危患者的UIC为115.40(61.23, 167.28) μg/L；ps-Tg为16.65(4.52, 43.45) μg/L。高危患者中，和ER组(20例)比较，non-ER组(48例)有较高的ps-Tg水平(n z＝-4.677, n P0.05)。多因素logistic回归分析示ps-Tg是中低危患者[比值比(n OR)＝6.157(95% n CI：1.046～36.227)；n OR＝22.965(95% n CI：3.591～146.857)，均n P<0.05]和高危患者[n OR＝9.696(95% n CI：1.379～68.169)，n P<0.05]non-ER的危险因素；中低危non-ER患者中UIC是non-ER的危险因素[n OR＝3.715(95% n CI：1.201～11.488)，n P<0.05]。n 结论:在中低危DTC患者中non-ER与UIC有关，但在高危患者中UIC不影响non-ER。中低危及高危患者较高的ps-Tg与non-ER有关。“,”Objective:To explore the impact of urinary iodine concentration (UIC) on response to n 131I treatment in differentiated thyroid cancer (DTC) patients with different risk stratifications.n Methods:A total of 181 patients with DTC (75 males, 106 females, age: (44.1±12.5) years), who received the first n 131I treatment in Tianjin Medical University General Hospital between January 2018 and February 2019, were retrospectively analyzed. Patients were divided into low- to intermediate-risk and high-risk groups. The treatment response was categorized into excellent response (ER) and non-excellent response (non-ER). Factors being evaluated including age, sex, preablative stimulated thyroglobulin (ps-Tg), UIC, etc. Mann-Whitney n U test, n χ2 test and logistic regression analysis were used for data analysis.n Results:The UIC and ps-Tg in the low- to intermediate-risk group (n n=113) was 111.60(55.80, 204.65) μg/L and 2.08(0.63, 4.91) μg/L, respectively. Compared with the ER subgroup ( n n=86), non-ER subgroup (n n=27) had higher UIC and ps-Tg level (n z values: -2.585, -4.511, both n P<0.05). In the high-risk group (n n=68), UIC was 115.40(61.23, 167.28) μg/L and ps-Tg was 16.65(4.52, 43.45) μg/L. Compared with the ER subgroup ( n n=20), non-ER subgroup (n n=48) had higher ps-Tg level (n z=-4.677, n P0.05). The multivariate logistic analysis indicated the ps-Tg level was the significant variable for non-ER in low- to intermediate-risk group (odds ratio(n OR)=6.157(95% n CI: 1.046-36.227); n OR=22.965(95% n CI: 3.591-146.857), both n P<0.05) and high-risk group (n OR=9.696 (95% n CI: 1.379-68.169), n P<0.05); a high UIC could be an indicator of non-ER only in the low- to intermediate-risk group (n OR=3.715(95% n CI: 1.201-11.488), n P<0.05).n Conclusions:The non-ER is associated with UIC in the low- to intermediate-risk group; however, UIC does not affect the non-ER in the high-risk group. Higher ps-Tg level is associated with non-ER in patients with low- to intermediate-risk and high-risk DTC.