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[目的]探讨胰岛素抵抗(IR)对多囊卵巢综合征(PCOS)患者内分泌代谢及卵巢超声指标的影响,并分析二者的相关性.[方法]120例PCOS患者以是否伴IR分为IR-PCOS组(n=65)和NIR-PCOS组(n=55).检测并比较两组血清雌二醇(E2)、黄体生成激素(LH)、卵泡刺激素(FSH)、胆固醇(TC)、空腹胰岛素(Fins)等内分泌代谢指标;阴道超声检查囊泡数量、卵巢体积(OV)、卵泡数目(NF)等.分析内分泌代谢及卵巢超声指标的相关性.[结果]IR-PCOS组空腹血糖(FPG)、甘油三酯(TG)、Fins、TC、LH水平明显高于NIR-PCOS组,FSH水平明显低于NIR-PCOS组(P＜0.05),两组其他内分泌代谢指标比较差异无统计学意义(P＞0.05).与NIR-P-COS组相比,IR-PCOS组囊泡数量、NF显著较多,血管化-血流指数(VFI)、OV显著增大(P＜0.05),两组卵巢间质面积(SA)及卵巢间质面积/总面积比值(SA/TA)比较差异无统计学意义(P＞0.05).相关性分析显示囊泡数量、NF、OV与PFG、Fins、TC、LH均呈正相关(P＜0.05),与FSH均呈负相关(P＜0.05);IR-PCOS组其他超声特征指标与其余内分泌指标无相关性.[结论]IR可增加PCOS患者内分泌代谢紊乱发生风险,改变卵巢超声指标,且伴IR-PCOS患者的内分泌代谢指标与卵巢超声指标具有一定的相关性.“,”[Objective]To investigate the effect of insulin resistance (IR) on endocrine metabolism and ovarian ultrasound features in patients with polycystic ovary syndrome (PCOS),and to analyze the relationships between the two.[Methods]A total of 120 patients with PCOS were divided into IR-PCOS group (with IR,n =65) and NIR-PCOS group (without IR,n =55).The related indicators of endocrine metabolism [serum estradiol (E2),luteinizing hormone (LH),follicle stimulating hormone (FSH),total cholesterol (TC),fasting insulin (Fins)] were detected.The transvaginal ultrasound was performed to analyze related characteristic indexes [number of vesicles,ovarian volume (OV),number of follicles (NF)].The correlation between endocrine metabolism and ovarian ultrasound indexes was analyzed.[Results] Compared to the NIR-PCOS group,the levels of fasting plasma glucose (FPG),triglyceride (TG),Fins,TC,and LH in IR-PCOS group were significantly higher (P ＜0.05),while FSH level was significantly lower (P ＜0.05).There was no significant difference between two groups in terms of other endocrine metabolism indexes,such as E2 (P ＞0.05).The number of vesicles,NF,OV,and vascularization flow index (VFI) were significantly higher than those in the NIRPCOS group (P ＜0.05),while there were no significant differences in ovarian stromal area (SA) or the ratio of ovarian stroma / total area (SA/TA) between the two groups (P ＞0.05).Correlation analysis showed that the number of vesicles,NF,and OV were positively correlated with PFG,Fins,TC,and LH (P ＜0.05) and negatively correlated with FSH (P ＜0.05).There was no correlation between other ultrasound characteristic indexes and other endocrine indexes in IR-PCOS group.[Conclusion]IR can increase the risk of endocrine metabolic disorders in patients with PCOS and change the characteristics of ovarian ultrasound.The endocrine metabolism showed a certain correlation with ovarian ultrasound features in patients with IR-PCOS.