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目的 :观察经过补肾方治疗的切卵模型大鼠血清对体外培养破骨细胞骨吸收功能的影响。方法 :取 1 0月龄 SD雌性大鼠 4 0只 ,其中 30只切除双侧卵巢造成骨质疏松症模型 ,1 0只仅切除少量脂肪而不损及卵巢 ,3个月成模后开始治疗 ,随机分为补肾方、倍美力和正常饮食对照 3组 ,每组 1 0只。治疗 3个月分离血清 ,用于细胞培养实验。自 1 d龄 SD大鼠四肢长骨分离破骨细胞 ,接种于象牙薄片底物上 ,以骨吸收陷窝数量变化为指标 ,观察各组血清的作用效果。结果 :与假切卵组比较 ,切卵组陷窝数量增加了 74 .1 % ,而补肾方和倍美力组的陷窝数量分别下降了 65 .7%和 5 9.3% ,与假切卵组之间的差异非常显著( P<0 .0 1 )。结论 :补肾方具有明显的抑制破骨细胞活性的作用。
Objective : To observe the effect of serum of osteotomy model rats treated with Bushen recipe on bone resorption of osteoclasts in vitro. METHODS: A total of 40 SD female rats at 10 months of age were used. 30 osteoporosis models were made by excision of bilateral ovaries, and only 10 fats were removed without damaging the ovaries. After 3 months, the treatment was started. , Randomly divided into Bushen Fang, Premarin and normal diet control 3 groups, 10 in each group. The serum was separated after 3 months of treatment for cell culture experiments. The osteoclasts were isolated from the long bones of SD rats in one-day-old SD rats and inoculated on the ivory wafer substrate. The changes in the amount of bone resorption lacunae were used as indicators to observe the effect of serum in each group. RESULTS: The number of lacunas in the oviparous group increased by 74.1% compared with the oviparous group, while the number of lacunas in the Bushenfang and the Premarin group decreased by 65.7% and 59.3%, respectively, and the number of ovipositions was decreased. The difference between groups was very significant (P < 0.01). Conclusion : Bushen Fang has obvious effect on inhibiting the activity of osteoclasts.