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测定了100例健康老年人(对照组)和220例各种老年疾病患者血清和尿中β2-MG、THP、α1-MG和Alb的含量。结果显示:心脏病、高血压、脑血管疾病、恶性肿瘤、风湿病、肺部感染等老年患者血清和尿中β2一MG、THP、α2-MG和Alb含量与对照组相比,至少有一项指标具有明显差别.表明这些疾病可以进一步影响肾功能或使体内该蛋白合成增多,而患骨质增生老年人与对照组比较无明显差异。结果提示:β2-MG、THP、α1-MG和Alb四项指标可以用于肾功能变化的早期评价.而β2-MG、α1-MG对某些疾病如肿瘤、风湿病的诊断及疗效判定亦具有一定的价值。
The serum and urinary levels of β2-MG, THP, α1-MG and Alb were measured in 100 healthy elderly controls (control group) and 220 elderly patients with various diseases. The results showed that there was at least one of β2-MG, THP, α2-MG and Alb in serum and urine of elderly patients with heart disease, hypertension, cerebrovascular disease, malignant tumor, rheumatism and lung infection Indicators have significant differences. Show that these diseases can further affect renal function or increase the synthesis of the protein in the body, and the elderly with osteoarthritis compared with the control group no significant difference. The results suggest that the four indexes of β2-MG, THP, α1-MG and Alb can be used in the early evaluation of renal function changes. The β2-MG, α1-MG for certain diseases such as cancer, rheumatism diagnosis and efficacy determination also has a certain value.