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本文对上海某橡胶厂轮胎和胶鞋制造工人进行了23年(1973~1995)的随访调查,应用标化死亡率和病例-队列方法,旨在研究橡胶职业暴露与食管癌之间的关系。研究发现,某些工种如成型、机修、胶鞋及炼胶等的食管癌相对危险度升高,并独立于与食管癌可能的非职业危险因素。进一步研究认为,橡胶化合物中的溶剂、滑石和碳黑等的暴露可能与食管癌有关。虽然研究的病例数较少,未有统计学显著性,但所提示的两者间关系值得进一步研究。
In this paper, a 23-year (1973-1995) follow-up survey of rubber tire and rubber shoe manufacturing workers in Shanghai was conducted. Standardized mortality and case-cohort methods were used to investigate the relationship between rubber occupational exposure and esophageal cancer. The study found that certain types of work such as molding, machine repair, rubber shoes and rubber esophageal cancer relative risk increased, and independent of possible non-occupational risk factors with esophageal cancer. Further research suggests that the exposure of solvents, talc and carbon black to rubber compounds may be related to esophageal cancer. Although the number of cases studied was not statistically significant, the relationship between the two suggested merit further study.