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目的 探讨食管癌的内分泌治疗。方法 用链霉菌抗生物素蛋白过氧化酶染色法对 6 6例食管癌组织进行雌激素受体 (ER)和孕激素受体 (PR)的测定 ;对 ER(+)和 PR(+)的食管癌患者随机分为给予内分泌治疗的实验组和不给予内分泌治疗的对照组。结果 6 6例食管癌中 ER阳性率为 72 .7% ,PR阳性率为 6 6 .7%。随着食管癌组织学分级的增加 ,ER、PR的阳性率减少 (P<0 .0 5 )。ER或 PR阳性的食管癌患者 ,实验组比对照组的 3年生存率高 (P<0 .0 5 )。结论 测定食管癌患者的 ER和 PR可以判断食管癌的恶性程度和指导食管癌的内分泌治疗。
Objective To investigate the endocrine treatment of esophageal cancer. Methods The estrogen receptor (ER) and progesterone receptor (PR) were measured in 66 patients with esophageal cancer by streptavidin peroxidase staining; for ER (+) and PR (+) Patients with esophageal cancer were randomly assigned to an experimental group given endocrine therapy and a control group not given endocrine therapy. Results The positive rate of ER in 66 cases of esophageal cancer was 72.7%, and the positive rate of PR was 66.7%. As the histological grade of esophageal cancer increased, the positive rate of ER and PR decreased (P<0.05). In patients with ER or PR positive esophageal cancer, the three-year survival rate was higher in the experimental group than in the control group (P<0.05). Conclusion The determination of ER and PR in patients with esophageal cancer can determine the degree of malignancy of esophageal cancer and endocrine therapy to guide esophageal cancer.