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通过分离病原体可确定布氏菌病的诊断。在未获得阳性培养时,特异性凝集试验滴度(>100)的诊断价值早已被承认。虽然 Ruiz—Castaneda 氏的改良技术增加了检出布氏菌的机会,但从慢性或亚急性病人中分离细菌仍然少。有人建议,骨髓、肝脏、淋巴结或其它组织培养可能提高诊断率,但没有用这些方法进行的对照研究。布氏菌是兼性细胞内寄生的病原菌,它局限在网状内皮系统的单核吞噬细胞内。鉴于我们用骨髓培养作伤寒热诊断令人鼓舞的结果和这二
The diagnosis of brucellosis can be determined by isolating the pathogen. The diagnostic value of specific agglutination test titers (> 100) has long been recognized without positive culture. Although Ruiz-Castaneda’s improved technique increases the chances of detecting Brucella, there is still less bacteria isolated from chronic or sub-acute patients. It has been suggested that bone marrow, liver, lymph node or other tissue culture may improve the diagnostic rate, but no controlled study with these methods. Brucella is a facultative intracellular pathogen that is confined within the reticuloendothelial system of mononuclear phagocytes. Given the encouraging results of our diagnosis of typhoid fever with bone marrow culture and these two