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到目前为止 DNA疫苗接种的两条主要途径为 DNA溶液的肌肉注射 ( im)和 DNA包被金颗粒的表皮基因枪轰击 ( gg)。作者在BALB/ c和 C5 7BL 两个品系小鼠中对 im和gg接种编码结核杆菌 Ag85 A的 DNA疫苗的免疫原性和保护效力进行了比较。 6～ 8周龄雌性 BALB/ c或 C5 7BL 小鼠间
The two main approaches to DNA vaccination so far have been intramuscular injection (im) of DNA solution and epidermal gene gun bombardment (gg) of DNA-coated gold particles. The authors compared the immunogenicity and protective efficacy of im and gg inoculation with a DNA vaccine encoding Mycobacterium tuberculosis Ag85 A in BALB / c and C5 7BL two strain mice. Between 6 and 8 weeks old female BALB / c or C5 7BL mice