论文部分内容阅读
酚妥拉明又名苄胺唑啉、立其丁,为咪唑啉衍生物,系短效α型抗肾上腺素药。以往主要用于治疗外周血管痉挛性疾病及肾上腺嗜铬细胞瘤的诊断和术前治疗,近年来其临床用途逐渐广泛,本文仅综述其在儿科的临床应用。一、药理作用:酚妥拉明以氢键或离子键方式与肾上腺素α受体结合,但其结合力较弱,治疗剂量尚不能完全对抗肾上腺素能α效应,当其浓度降低或儿茶酚胺浓度升高时,则结合易解离而失效。其主要药理作用有:(一)本药不仅能阻断α受体,尚能直接松弛血管及支气管平
Phentolamine, also known as benzylazoline, Li Ding Ding, imidazoline derivatives, Department of short-acting α-type anti-adrenergic drugs. In the past mainly for the treatment of peripheral vasospastic diseases and adrenal pheochromocytoma diagnosis and preoperative treatment, in recent years its clinical use gradually widespread, this article reviews only its clinical application in pediatrics. First, the pharmacological effects: Phentolamine hydrogen bond or ionic bond with the adrenaline α receptor, but its binding is weak, the therapeutic dose can not completely antagonize the α-effect of adrenergic, when its concentration decreased or catecholamine concentration When elevated, the combination of easy dissociation and failure. Its main pharmacological effects are: (a) the drug can not only block the α receptor, still can directly relax the blood vessels and bronchial smooth