以乙酰乙酸乙酯为起始原料,经四步反应制备了关键中间体3-甲基-5-苯基异噁唑甲酰肼(2);2分别与取代苯腙基乙酰乙酸乙酯和取代苯腙基乙酰丙酮反应合成了一系列新型的1-(3′-甲基-5′-苯基-异噁唑-4′-甲酰基)-3-甲基-4-苯腙基吡唑酮和1-(3′-甲基-5′-苯基-异噁唑-4′-甲酰基)-3,5-二甲基-4-芳偶氮基吡唑酮衍生物,其结构经1H NMR,IR和MS表征。 The key intermediate 3-methyl-5-phenylisoxazole carboxylic acid hydrazide (2) was prepared by four-step reaction using ethyl acetoacetate as the starting material; 2 respectively with substituted phenylhydrazone ethyl acetoacetate and A series of novel 1- (3’-methyl-5’-phenyl-isoxazole-4’- formyl) -3-methyl-4-phenylhydrazonopyridine Oxazolone and 1- (3’-methyl-5’-phenyl-isoxazole-4’-formyl) -3,5-dimethyl- The structure was characterized by 1H NMR, IR and MS.