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本文作者对急性丙型肝炎病毒感染的特征作了前瞻性研究,并评估了临床或病毒因素对结果的影响。 研究对象选择1988～1989年间、年满18岁、无AIDS且承认有静脉吸毒史10年以上的142病人。这些病人至少被随访1年,并且抗-HCV阴性。其血标本每6个月采集1次,1996年5月为最后1次血标本采集。作者对他们观察了HCV血清转换情况:先以第二代EIA法测定抗-HCV,阳性者再行HCV RNA定量分析或第二代重组免疫印迹试验(RIBA)以确认HCV血清转换情况。随
The authors prospectively studied the characteristics of acute hepatitis C virus infection and assessed the impact of clinical or viral factors on outcomes. Subjects selected from 1988 to 1989, 18 years of age, no AIDS and admitted to a history of intravenous drug abuse more than 142 years 142 patients. These patients were followed for at least 1 year and anti-HCV negative. The blood samples collected once every 6 months, in May 1996 for the last blood samples collected. The authors looked at their HCV seroconversion: anti-HCV was first measured by the second-generation EIA, followed by HCV RNA quantification or second-generation Western blotting (RIBA) to confirm HCV seroconversion. With