[英]?WeissmanKJ∥Trends Biotechnol.-2007,25(4).-139～141许多药用天然产物结构独特,难以用全合成或者半合成的方法制备。早期的合成方法为基于前体的生物合成,即将合成的化合物经过细菌或真菌的生物转化生成天然药物。但是与内源性前体存在竞争,终产物产率较低。如果将此细 Weissman KJ Trends Biotechnol.-2007,25 (4) .- 139 ~ 141 Many of the medicinal natural products are unique in structure and are difficult to prepare by either all-synthetic or semi-synthetic methods. Early synthetic methods were precursor-based biosynthesis, which is the natural synthesis of a compound by the bacterial or fungal biotransformation. However, competition with endogenous precursors leads to lower yields of final products. If this will be fine