目的制备紫杉醇纳米混悬剂,并表征其理化性质。方法采用重结晶结合高压均质法制备紫杉醇纳米混悬剂,以纳米粒的粒径和Zeta电位为指标,考察紫杉醇纳米混悬剂的影响因素,并对制得的纳米混悬剂进行表征。结果紫杉醇纳米混悬剂的粒径为214.4 nm,跨距为0.46,平均Zeta电位为-22.7 mV,体系稳定。结论制备的纳米混悬剂处方简单、工艺稳定。 Objective To prepare paclitaxel nanosuspension and characterize its physicochemical properties. Methods paclitaxel nanosuspension was prepared by recrystallization and high pressure homogenization. The influence factors of paclitaxel nanosuspension were investigated by the size of nanoparticles and Zeta potential. The nanosuspensions were characterized. Results The paclitaxel nanosuspension had a particle size of 214.4 nm, a span of 0.46 and an average Zeta potential of -22.7 mV. The system was stable. Conclusion The preparation of nanosuspension is simple and the process is stable.