泛素-蛋白酶体系统(UPS)主要由泛素、泛素活化酶、泛素结合酶、泛素连接酶、26S蛋白酶体及去泛素化酶等组成,是降解细胞内蛋白质的非溶酶体途径。UPS与多种疾病的发生发展有关,在肝病研究中也具有重要的病理生理意义。本文就UPS及其与肝病关系的研究现状作一综述。 Ubiquitin-proteasome system (UPS) is mainly composed of ubiquitin, ubiquitin-activating enzyme, ubiquitin-binding enzyme, ubiquitin ligase, 26S proteasome and deubiquitinase and other components, is the degradation of intracellular protein non-soluble enzyme Body way. UPS is associated with the occurrence and development of many diseases and also has important pathophysiological significance in the study of liver diseases. This article reviews the research status of UPS and its relationship with liver disease.