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The effects of L-tetrahydropalmatine (L-THP) on the cultured rat cardiomyocytes during hypoxia and reoxygenation and the mechanism of L-THP treating reperfusion-arrythmias were stud- ied. The concentration of intracellular free calcium ([Ca2+]i) of single cultured ventricular myocyte was determined by using EPC-9 light-electricity measurement system. It was found that L-THP (100μmol/L) could reduce the [Ca2+]i augmentation in single cultured ventricular myocyte during hypoxia and reoxygenation. Verapamil (10 μmol/L ) had the similar effect. It was concluded that L- THP could inhibit the Ca2+ overload of cultured rat cardiomyocytes during hypoxia and reoxygena- tion.
The effects of L-tetrahydropalmatine (L-THP) on the cultured rat cardiomyocytes during hypoxia and reoxygenation and the mechanism of L-THP treating reperfusion-arrythmias were stud -ied. The concentration of intracellular free calcium ([Ca 2+] i) of single cultured ventricular myocyte was determined by using EPC-9 light-electricity measurement system. It was found that L-THP (100 μmol / L) could reduce the [Ca2 +] i augmentation in single cultured ventricular myocyte during hypoxia and reoxygenation. Verapamil / L) had the similar effect. It was concluded that L- THP could inhibit the Ca2 + overload of cultured rat cardiomyocytes during hypoxia and reoxygena- tion.