Ca~(2+)在细胞内有许多重要的功能,它参与不同酶系和多种类型细胞活动的调节。细胞内Ca~(2+)的这些功能需很低的Ca~(2+)浓度(μmol/L或更低),维持细胞浆低Ca~(2+)浓度是与细胞Ca~(2+)调节装置有关,心肌细胞的这类装置包括肌膜、肌浆网、线粒体以及一些与Ca~(2+)结合的蛋白(如钙调素)和小分子物质,其中线粒体是重要的机构之一。Vasington等首次报道了肾脏线粒体对Ca~(2+)的摄取作用,并注意到这一过 Ca 2+ has many important functions in the cell and it is involved in the regulation of the activity of different enzymes and various types of cells. These functions of intracellular Ca 2+ require low Ca 2+ concentration (μmol / L or less), maintain low Ca 2+ concentration in cytoplasm, ) Regulatory devices, such devices of cardiomyocytes include the sarcolemma, sarcoplasmic reticulum, mitochondria, and some proteins that bind to Ca 2+, such as calmodulin, and small molecules, of which mitochondria are important mechanisms one. For the first time, Vasington et al. Reported the uptake of Ca ~ (2+) by the renal mitochondria and noticed that this