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目的:观察补肾活血方联合常规疗法治疗慢性肾功能不全的效果。方法:选取112例慢性肾功能不全患者为研究对象,按照随机数字表法分为观察与对照组各56例。对照组给予常规治疗,观察组在常规治疗上加用补肾活血方治疗,对比2组的临床疗效、治疗前后肾功能指标变化以及不良反应发生情况。结果:观察组总有效率为91.1%,对照组总有效率为73.2%,2组总有效率比较,差异有统计学意义(P<0.05)。治疗后,2组血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)和24 h尿蛋白定量均较治疗前有明显的改善,观察组各指标改善程度均优于对照组,差异均有统计学意义(P<0.05)。治疗过程中,2组患者均未见不良反应发生,患者依从性较好。结论:应用补肾活血方联合常规疗法治疗慢性肾功能不全具有较好的临床疗效,可有效改善肾功能,不良反应少,安全性高。
Objective: To observe the effect of Bushen Huoxue prescription combined with routine therapy on chronic renal insufficiency. Methods: One hundred and twenty-two patients with chronic renal insufficiency were selected as study subjects and divided into observation and control group (n = 56) according to random number table. The control group was given conventional treatment. The observation group was treated with Bushen Huoxue Recipe in routine treatment. The clinical curative effect was compared between the two groups. The changes of renal function indexes and the incidence of adverse reactions before and after treatment were observed. Results: The total effective rate was 91.1% in the observation group and 73.2% in the control group. The total effective rate in the two groups was statistically significant (P <0.05). After treatment, the serum creatinine (SCr), blood urea nitrogen (BUN), uric acid (UA) and 24 h urinary protein in two groups were significantly improved than those before treatment, and the improvement of each index in the observation group was better than that in the control group There was statistical significance (P <0.05). During the course of treatment, no adverse reactions occurred in both groups, and patients were better compliant. Conclusion: The application of Bushen Huoxue Recipe combined with routine therapy in the treatment of chronic renal insufficiency has good clinical curative effect, which can effectively improve renal function with less adverse reactions and high safety.