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迅速积累的实验证据表明,主要组织相容性抗原在宿主抵御肿瘤的发生和扩散中起重要作用。各种自发和实验诱发的动物肿瘤细胞表现出由主要组织相容性复合物(Major HistocompatibilityComplex,MHC)编码的Ⅰ、Ⅱ类抗原量和质的差别。尽管在某些实验模型中选择性地缺少MHCⅠ类分子与肿瘤的生长和转移能力有关,但在另外的实验里却得到了明显矛盾的结果,但其机制所知甚少。我们对人类肿瘤的MHC抗原表达的改变知道的更
Rapidly accumulating experimental evidence indicates that major histocompatibility antigens play an important role in the host’s resistance to the occurrence and spread of tumors. Various spontaneous and experimentally induced animal tumor cells exhibited differences in the amount and quality of class I and class II antigens encoded by major histocompatibility complex (MHC). Although the selective absence of MHC class I molecules in some experimental models is related to the growth and metastasis capacity of tumors, there are clearly contradictory results in other experiments, but the mechanisms are poorly understood. We know even more about changes in the expression of MHC antigens in human tumors.