1957年,干扰素首次由Issacs和Linde-mann作为一种自然发生的抗病毒物质而提出,其后不久发现该物质亦具抗肿瘤特性。直至1981年,随着重组DNA方法的问世而得以大量生产高纯度的干扰素之后,大规模的临床Ⅰ期和Ⅱ期试验方开始实施。本文拟就上述结果予以概述,并就干扰素治疗基本原则提出浅见,以期对今后一些生物试剂的试验和应用研究有所裨益。 In 1957, interferon was first proposed by Issacs and Lindemann as a naturally occurring antiviral substance, and it was soon discovered that this substance also had antitumor properties. Until 1981, large quantities of clinical Phase I and Phase II trials began to be implemented after mass production of high-purity interferon with the introduction of recombinant DNA methods. This article will outline the above results, and put forward a brief opinion on the basic principles of interferon therapy, with a view to the future of some biological reagents in the trial and application of research has benefited.