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Crafoord 等(1936年)最早开展食管静脉曲张的硬化剂注射疗法,用的是奎宁-乌拉坦。Macbeth(1955)用鱼肝油酸钠进行治疗,因当时门腔分流术的广泛开展而逊色。此后因 Johnston 等(1973)的优良结果,使此法重获新生,他采用的是油酸氨乙醇。关于持续活动性食管静脉曲张出血的处理争论颇大。Johnson 仅对由窥镜下出血点清晰可见的少数病人(7%)进行治疗,而 Lewis 对所有食管静脉曲张出血的病人均进行硬化剂治疗。作者对疑为食管静脉曲张出血病人均行血管加压素治疗,以0.4单位/分的速度持续滴注。在急症内窥镜检查中证明为食管静脉曲张出血而出血已停止者,继续用血管加压素
Crafoord et al. (1936) pioneered esophageal varicocele sclerotherapy, using quinine-urethane. Macbeth (1955) was treated with sodium morrhuate, which was less favored at the time when portal shunting was widespread. Since then, the excellent result of Johnston et al. (1973) brought this method back to life, using aminoethyl oleate. The treatment of persistent active esophageal variceal bleeding is controversial. Johnson treated only a small number of patients (7%) that were clearly visible by the bleeding under the endoscope, and Lewis treated all patients with esophageal variceal bleeding with sclerotherapy. The author of the suspected esophageal variceal bleeding patients were treated with vasopressin, 0.4 units / min speed infusion. In emergency endoscopy proved to be bleeding esophageal varices bleeding has stopped, continue to use vasopressin