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目的:观察芍药苷对高脂饲料喂养幼龄大鼠的进食量和体重的影响。方法:使用高脂饲料饲养大鼠造模,腹腔注射芍药苷注射液治疗,计算各组每周平均体重增加率和平均24 h进食量并绘制变化图。结果:芍药苷治疗组的摄食量和体重增长百分率在实验第5周之后逐渐被抑制,与未用芍药苷干预的高脂饲料喂养组相比有显著性差异(P<0.05)。结论:芍药中的有效单体成份芍药苷能显著降低高脂饲料喂养幼龄大鼠摄食量和体重增长百分率。
Objective: To observe the effect of paeoniflorin on food intake and body weight of young rats fed with high fat diet. Methods: The rats were fed with high-fat diet and treated with intraperitoneal injection of paeoniflorin. The average weekly weight gain and the average food intake for 24 h were calculated and the changes were plotted. Results: The percentage of food intake and weight gain of paeoniflorin group was gradually decreased after 5 weeks of experiment, which was significantly different from that of high fat diet group without paeoniflorin treatment (P <0.05). CONCLUSION: Paeoniflorin, an effective monomer in peony, can significantly reduce the food intake and body weight gain percentage of young rats fed with high fat diet.