论文部分内容阅读
1例58岁男性患者接受四联疗法治疗幽门螺杆菌感染，给药方案为口服阿莫西林（1 g，2次/d）、呋喃唑酮（0.1 g，2次/d）、雷贝拉唑（20 mg、2次/d）和枸橼酸铋钾（0.6 g、2次/d），共用药4周。停药7 d后实验室检查示血肌酐（Scr）469 μmol/L，尿素氮（BUN）19.2 mmol/L；肾组织活检病理检测结果提示急性肾小管损伤。患者半年前体检结果显示Scr 78 μmo/L。考虑患者的急性肾损伤与四联疗法有关。给予甲泼尼龙、瑞巴派特和碳酸钙口服。4周后复查，Scr 171 μmol/L，BUN 14.4 mmol/L，继续上述治疗；12周后复查，Scr 140 μmol/L，BUN 11.4 mmol/L。“,”A 58-year-old male patient received quadruple therapy with amoxicillin 1 g, furazolidone 0.1 g, rabeprazole 20 mg, and bismuth potassium citrate 0.6 g twice daily for n Helicobacter pylori infection for 4 weeks. Seven days after drug withdrawal, the laboratory tests showed serum creatinine (Scr) 469 μmol/L and blood urea nitrogen (BUN) 19.2 mmol/L. Renal biopsy showed acute tubular injury. The Scr level was 78 μmol/L in the physical examination of 6 months ago. Acute kidney injury was considered to be associated with the quadruple therapy. Methylprednisolone, rebamipide, and calcium carbonate were given orally. Four weeks later, the laboratory tests showed Scr 171 μmol/L and BUN 14.4 mmol/L and the above treatments were continued; 12 weeks later, his Scr was 140 μmol/L and BUN was 11.4 mmol/L.n