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目的探讨网织红细胞血红蛋白含量(CHr)对缺铁性贫血(IDA)进行诊断及鉴别诊断的价值。方法用ADVIA2120全自动血细胞分析仪检测IDA组、非IDA贫血组和健康对照组的CHr,通过两样本均数的t检验,比较IDA组与健康对照组I、DA组与非IDA贫血组、非IDA贫血组与健康对照组之间CHr是否差异有统计学意义。计算CHr诊断IDA的灵敏度及特异性,用ROC曲线评价CHr诊断IDA的应用价值。结果健康对照组CHr为(34.2±0.8)pg,IDA组CHr为(25.2±4.2)pg,非IDA贫血组Chr为(34.7±3.1)pg,IDA组与健康对照组CHr差异有统计学意义(P<0.001),IDA组与非IDA贫血组CHr差异有统计学意义(P<0.001),非IDA贫血组与健康对照组CHr差异无统计学意义(P>0.05)。CHr诊断IDA灵敏度为90%,特异性96.7%,阳性预测值96.4%,阴性预测值93.5%,ROC曲线下面积为0.968。结论 CHr对IDA有早期诊断、确定诊断及鉴别诊断价值,在临床有良好的应用前景。
Objective To investigate the diagnostic value of reticulocyte hemoglobin (CHr) in the diagnosis and differential diagnosis of iron deficiency anemia (IDA). Methods The CHr of IDA group, non-IDA anemia group and healthy control group were detected by ADVIA2120 automatic hematology analyzer. The t-test of two-sample mean was used to compare the difference between IDA group and healthy control group, DA group and non-IDA anemia group There was a significant difference in CHr between IDA anemia group and healthy control group. The sensitivity and specificity of CHr in diagnosing IDA were calculated, and the diagnostic value of CHr in diagnosis of IDA was evaluated by ROC curve. Results CHr was (34.2 ± 0.8) pg in healthy control group, CHr in IDA group was (25.2 ± 4.2) pg, Chr was (34.7 ± 3.1) pg in non-IDA anemia group, and CHr in IDA group was significantly different from that in healthy control group (P <0.001). The difference of CHr between IDA group and non-IDA anemia group was statistically significant (P <0.001). There was no significant difference in CHr between non-IDA anemia group and healthy control group (P> 0.05). The diagnostic sensitivity of CHr was 90%, specificity 96.7%, positive predictive value 96.4%, negative predictive value 93.5%, and the area under the ROC curve was 0.968. Conclusion CHr has an early diagnosis of IDA, diagnosis and differential diagnosis to determine the value of the clinical application has a good prospect.