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ｐ１６基因失活存在于多种肿瘤中，ｐ１６基因的纯合性缺失和５′ＣｐＧ岛甲基化是其失活的主要机制，本文综述了近年来国外学者对ｐ１６基因５′ＣｐＧ岛甲基化的研究工作，并简述５′ＣｐＧ岛甲基化与基因表达、ｐ１６基因失活与肿瘤发生的关系
Inactivation of p16 gene exists in many tumors. The homozygous deletion of p16 gene and the methylation of 5’CpG island are the main mechanisms of inactivation. In this paper, the recent researches on p16 gene 5’CpG island methyl Of the research work, and briefly 5’CpG island methylation and gene expression, p16 gene inactivation and tumorigenesis