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本实验观察了正常和高磷摄入时,补充高量维生素D_3对尾吊(30天)大鼠股骨、腓肠肌和肾成分及其它指标的影响。结果表明,在膳食钙磷含量和比值正常时(Ca:P=0.6%:0.6%),与适量维生素D摄入(膳食维生素D含量为2000IU/kg)比较,高维生素D摄入(10000IU/kg)不但不能减轻悬吊大鼠股骨的骨丢失,反而导致肾脏出现轻度病理变化,腓肠肌萎缩加重,高钙血和血清碱性磷酸酶活性(ALP)增强。在膳食磷含量增加时(1.8%),高维生素D摄入能显著减轻悬吊大鼠股骨的骨丢失,但也加重高磷摄入对肾脏的损伤,并有体重减轻和腓肠肌萎缩加重等副作用。结果提示,在失重和模拟失重条件下,机体对维生素D毒性作用的耐受能力可能减低,补充高剂量维生素D是有害的。
In this study, we observed the effects of high vitamin D 3 supplementation on the femur, gastrocnemius and kidney components and other indexes of tail-suspended rats (30 days) during normal and high phosphorus intake. The results showed that high vitamin D intake (10000IU / kg) compared with normal intake of vitamin D (dietary vitamin D content of 2000IU / kg) at normal dietary calcium and phosphorus levels (Ca: P = 0.6% kg) not only failed to relieve bone loss in the femur of rats, but also resulted in mild pathological changes in the kidneys, increased gastrocnemius atrophy, hypercalcemia, and elevated serum alkaline phosphatase activity (ALP). In the dietary phosphorus content increased (1.8%), high vitamin D intake can significantly reduce bone loss in the femur of suspended rats, but also aggravate the high phosphorus intake of kidney damage, and weight loss and increased gastrocnemius and other side effects . The results suggest that under conditions of weightlessness and simulated weightlessness, the body’s tolerance to the toxic effects of vitamin D may be reduced, and the addition of high doses of vitamin D is detrimental.