基于空心光纤构建微管生物传感器,进行了空心光纤的回音壁谐振模(WGM)理论分析,阐述了基于折射率变化检测的微管生物传感器工作原理。采用ZF13棱镜通过倏逝场耦合成功激发了微管的回音壁谐振模。利用不同浓度的乙醇水溶液初步展示了微管生物传感器回音壁谐振模谐振波长对折射率的敏感性,在1555.0 nm谐振波长处,当入射光角度为45°时,获得2.2 nm/RIU(RIU为折射率单元)的传感灵敏度,在入射光角度为36°时,获得21.2 nm/RIU的传感灵敏度。 Micropipe biosensors were constructed based on hollow fiber, and the theoretical analysis of WGM of hollow fiber was carried out. The working principle of microtubule biosensor based on the change of refractive index was described. The ZF13 prism successfully stimulated the microtubule echo wall resonance mode by evanescent field coupling. The sensitivities of the resonant wavelength of the resonant wall of the resonant wall of the microtubule biosensor to the refractive index of the microtubule biosensor were preliminarily shown using different concentrations of ethanol aqueous solution. When the incident light angle was 45 ° at 1555.0 nm, 2.2 nm / RIU Refractive index unit), a sensing sensitivity of 21.2 nm / RIU is obtained at an incident light angle of 36 °.