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目的了解江西区域肾脏病的临床表现,病理类型和流行病学特点。方法对1997年5月～2003年12月在我科行肾活检的1602例肾脏病患者的性别、年龄、病理类型及临床表现等进行分析。结果原发性肾小球疾病男性占65.8%,继发性肾小球疾病29.9%。女性占继发性肾小球疾病的70.1%。好发年龄段为15～39岁。其中毛细血管内增生性肾小球肾炎(EnPGN)和紫癜性肾炎(HSPN)好发于<14岁。>49岁者糖尿病肾病(DN)、肾淀粉样变(AN)、微型多动脉炎(MPA)、多发性骨髓瘤肾损害(MultipleMyeloma)多发,其他类型多发于20～39岁之间;临床表现:(1)慢性肾炎综合征(CNS)37.57%;(2)肾病综合征(NS)27.90%;(3)肉眼血尿(GH)12.11%;(4)慢性肾衰(CRF)9.49%;(5)急性肾衰(ARF)5.50%;(6)急进性肾炎(RPGN)3.93%;(7)急性肾炎综合征(ANS)3.50%,CNS最常见为系膜增生性肾炎(MsPGN)24.75%和IgA肾病(IgAN)21.26%。NS最常见为MsPGN29.30%、膜性肾病(MN)12.98%、HSPN12.98%。ARF最常见于急性间质性肾炎(AIN)和急性肾小管坏死(ATN)。CRF最常见于IgAN,肾小球硬化(SCGN)和局灶节段性肾小球硬化(FSGS)。江西省内不同地区患者的病理类型构成比相近无显著性差异(P>0.05)。结论原发性肾小球疾病是导致CRF的主要病因,男性和青壮年多发。继发性肾小球疾病女性多发。
Objective To understand the clinical manifestations, pathological types and epidemiological characteristics of kidney disease in Jiangxi Province. Methods From May 1997 to December 2003 in our department of kidney biopsy of 1602 cases of kidney disease patients with gender, age, pathological type and clinical manifestations were analyzed. Results The primary glomerular disease accounted for 65.8% of men and 29.9% of secondary glomerular diseases. Women accounted for 70.1% of secondary glomerular diseases. Good hair age range of 15 to 39 years old. Capillary proliferative glomerulonephritis (EnPGN) and purpuric nephritis (HSPN) occur in <14 years old. > 49 years of age diabetic nephropathy (DN), renal amyloidosis (AN), polyarteriitis (MPA), multiple myeloma and multiple myeloma, other types of multiple in 20 to 39 years of age; clinical manifestations : (1) 37.57% of patients with chronic nephritic syndrome (CNS); (2) 27.90% of patients with nephrotic syndrome; (3) 12.11% of gross hematuria; (4) 9.49% of patients with chronic renal failure 5) 5.50% of acute renal failure (ARF); (6) 3.93% of acute renal failure (RPGN); (7) 3.50% of acute nephritic syndrome (ANS); 24.75% of most common CNS with mesangial proliferative glomerulonephritis (MsPGN) And IgA nephropathy (IgAN) 21.26%. The most common cases of NS were MsPGN29.30%, membranous nephropathy (MN) 12.98% and HSPN12.98%. ARF is most commonly found in acute interstitial nephritis (AIN) and acute tubular necrosis (ATN). CRF is most commonly found in IgAN, glomerulosclerosis (SCGN) and focal segmental glomerulosclerosis (FSGS). There was no significant difference in the pathological type of patients in different areas of Jiangxi (P> 0.05). Conclusions Primary glomerular disease is the major cause of CRF, with multiple men and young adults. Secondary glomerular disease multiple women.