论文部分内容阅读
目的探讨清开灵注射液对内毒素性发热家兔血管内皮细胞分泌功能的作用。方法复制内毒素(ET)性发热家兔模型,观察清开灵对体温的影响,并用放免法测定内皮素以及血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的含量,用发色底物法测定血浆组织纤溶酶原激活物(t-PA)及其组织纤溶酶原激活物抑制剂(PAI)的活性。结果清开灵对ET性发热家兔有显著性的解热效应(P(0.01),清开灵+ET组内皮素、TXB2的含量(P(0.01)以及PAI的活性(P(0.05)明显低于ET组;而6-keto-PGF1α的含量(P(0.05)和t-PA的活性(P(0.01)明显高于ET组。结论清开灵可能通过改善内毒素性发热家兔血管内皮细胞的分泌功能,起到扩张微血管,加快体表散热,从而对发热家兔的解热效应起到一定的整合作用。
Objective To investigate the effect of Qingkailing injection on the secretion of vascular endothelial cells in endotoxin-induced febrile rabbits. Methods The endotoxin (ET) febrile animal model was reproduced and the effect of Qingkailing on body temperature was observed. Endothelin, thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α) were measured by radioimmunoassay. The content of plasma tissue plasminogen activator (t-PA) and its tissue plasminogen activator inhibitor (PAI) activity was determined by chromogenic substrate method. Results Qingkailing had a significant antipyretic effect on ET-induced febrile rabbits (P <0.01). Qingkailing + ET group had endothelin, TXB2 content (P <0.01) and PAI activity (P <0.05). In the ET group, the content of 6-keto-PGF1α (P (0.05) and t-PA activity (P (0.01) was significantly higher than that of the ET group. Conclusion Qingkailing may improve endotoxin-induced fever in rabbit vascular endothelial cells. The secretory function plays a role in dilating the microvessels and accelerating the heat dissipation of the body surface, thereby playing a certain role in the antipyretic effect of the fevered rabbits.