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目的探讨玻璃体腔注射阿霉素治疗外伤性玻璃体出血的效果。方法外伤性玻璃体出血模型新西兰大白兔20只随机分为阿霉素组和生理盐水组,每组10眼。直接眼底镜观察玻璃体出血指数、增生性玻璃体视网膜病变(PVR)程度;ELISA法测定玻璃体液中细胞因子浓度。结果阿霉素组PVR程度、玻璃体腔白细胞介素-1β(IL-1β)、转化生长因子β1(TGF-β1)浓度均低于生理盐水组(P<0.05)。两组玻璃体出血指数、玻璃体腔基质金属蛋白9、血小板源性生长因子、表皮生长因子浓度无统计学差异。结论玻璃体腔注射阿霉素可以降低外伤性PVR程度,这可能与下调玻璃体腔IL-1β、TGF-β浓度有关。
Objective To investigate the effect of intravitreal injection of doxorubicin on traumatic vitreous hemorrhage. Methods Traumatic vitreous hemorrhage model 20 New Zealand white rabbits were randomly divided into doxorubicin group and saline group, 10 eyes in each group. Direct ophthalmoscopy vitreous hemorrhage index, proliferative vitreoretinopathy (PVR) degree; ELISA method for determination of cytokines in vitreous humor concentration. Results The levels of PVR, IL-1β and TGF-β1 in adriamycin group were lower than those in saline group (P <0.05). There was no significant difference in the indexes of vitreous hemorrhage, matrix metalloproteinase 9, platelet-derived growth factor and epidermal growth factor in vitreous cavity. Conclusion Intravitreal injection of doxorubicin can reduce the degree of traumatic PVR, which may be related to downregulation of IL-1β and TGF-β in the vitreous.