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目的:探讨三仁汤加减及药袋热敷联合西医对慢性盆腔炎伴积液患者粘连相关免疫分子的影响。方法:选取2013年4月至2015年4月我科收治的慢性盆腔炎患者98例为研究对象,采用随机数表法分为观察组和对照组各49例,对照组采用西药(左氧氟沙星+甲硝唑)治疗,观察组在此基础加服三仁汤,并配合药袋热敷治疗,均治疗2个月。比较两组治疗有效率,采用酶联免疫吸附实验(ELISA)分析血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-4(IL-4)水平,并应用生活质量评价量表(SF-36)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评价预后水平,同时记录不良反应发生率。结果:观察组治疗有效率91.8%高于对照组79.6%(P<0.05);治疗后观察组TNF-α(43.12±1.05)pg/m L、IL-1β(75.21±4.81)pg/m L及SAS评分(21.41±3.64)分、SDS评分(22.59±1.68)分低于对照组(P<0.05),观察组IL-4(47.52±4.63)pg/m L、SF-36评分(89.34±4.21)分高于对照组(P<0.05);观察组不良反应发生率10.2%与对照组6.1%比较无显著差异(P>0.05)。结论:三仁汤加减及药袋热敷联合西医治疗可有效调节慢性盆腔炎伴积液患者血清免疫分子水平,同时改善预后,值得在临床推广。
Objective: To investigate the effect of Sanren decoction combined with pouch hot compress combined with western medicine on adhesion-related immune molecules in patients with chronic pelvic inflammatory disease. Methods: A total of 98 patients with chronic pelvic inflammatory disease in our department from April 2013 to April 2015 were enrolled in this study. Each group was divided into observation group (49 cases) and control group (49 cases) by random number table. The control group was treated with western medicine (levofloxacin + Nitazoxanide). The observation group was served on this basis with Sanren Decoction, and treated with hot packs of medicine bags for 2 months. The levels of TNF-α, IL-1β and IL-4 were determined by enzyme-linked immunosorbent assay (ELISA) (SF-36), anxiety self-rating scale (SAS) and depression self-rating scale (SDS) were used to evaluate the prognosis. At the same time, the incidence of adverse reactions was recorded. Results: The effective rate of treatment group was 91.8%, which was significantly higher than that of control group (79.6%, P <0.05). After treatment, the levels of TNF-α (43.12 ± 1.05) pg / m L and IL-1β (75.21 ± 4.81) pg / (21.41 ± 3.64), SAS score (21.41 ± 3.64), SDS score (22.59 ± 1.68) were lower than the control group (P <0.05) 4.21) points higher than the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (10.2% vs 10.2%, P> 0.05). Conclusion: Sanren decoction combined with medicine bag hot compress combined with western medicine can effectively regulate the level of serum immune molecules in patients with chronic pelvic inflammatory disease and improve prognosis, which is worthy of clinical promotion.