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自1966年羊水细胞核型分析成功以来,羊膜穿刺术广泛用于高龄孕妇的产前诊断。羊膜穿刺术的主要缺点是检查最安全的时间在妊娠16周后,检查后如需中止妊娠,为时未免太晚。因而在胎儿染色体异常高危人群中羊膜穿刺术的接受率低于期望数。英国University College医院从1982年就建立了绒毛膜活检方法以诊断地中海贫血,由于该方法能对妊娠11周前的产妇进行产前诊断,近来又将这一技术在部分病例中代替羊膜穿刺术,用于遗传病筛选。为了增加产前诊断的接受率并为高龄孕妇
Amniocentesis has been widely used in the prenatal diagnosis of advanced pregnant women since the success of amniotic fluid karyotype analysis in 1966. The main disadvantage of amniocentesis is the most safe time to check after 16 weeks of pregnancy, after checking for the termination of pregnancy, too late too late. Therefore, the risk of amniocentesis in the population at high risk of fetal chromosomal abnormalities was lower than expected. Since 1982, the University College Hospital in England has established a method of chorion biopsy for the diagnosis of thalassemia. Since this method can be used to make prenatal diagnosis of the mother 11 weeks before gestation, this technique has recently replaced amniocentesis in some cases, For genetic disease screening. In order to increase the acceptance rate of prenatal diagnosis and for pregnant women