肿瘤相关的炎症表现包括淋巴细胞侵润到肿瘤组织,肿瘤坏死因子(tumor necrosis factor,TNF)和白介素-1(interleukin-1,IL-1)等细胞因子的表达以及趋化因子CCL2和CXCL8等的表达等等。肿瘤相关巨噬细胞(tumor-asso-ciated macrophage,TAM)是炎症与肿瘤相关性中的重要调节者,在肿瘤微环境中表现促肿瘤的性质:表达生长因子和基质蛋白酶,促进血管生成,抑制免疫反应。因此,T A M可以成为肿瘤治疗中除传统治疗对象外的另一个靶标。 Tumor-related inflammatory manifestations include lymphocyte infiltration into tumor tissues, expression of cytokines such as tumor necrosis factor (TNF) and interleukin-1 (IL-1), and chemokines CCL2 and CXCL8 The expression and so on. Tumor-associated macrophages (TAMs) are important regulators of inflammation in tumor-associated tumors and exhibit tumor-promoting properties in the tumor microenvironment: expression of growth factors and matrix proteases, promotion of angiogenesis, inhibition immune response. Thus, T A M can be another target for cancer therapy beyond traditional treatment.