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目的探讨子宫内膜异位症患者(EMs)血清胰岛素样生长因子-I(IGF-1)和血管内皮生长因子(VEGF)的表达及与疾病严重程度的关系。方法选取病理确诊的EMs患者60例为观察组,R-AFS分期Ⅰ期14例、Ⅱ期16例、Ⅲ期18例、Ⅳ期12例,另选取60例良性卵巢成熟畸胎瘤非EMs患者为对照组。抽取两组患者空腹静脉血,采用ELISA法检测患者及不同R-AFS分期血清VEGF、IGF-1水平。结果观察组患者血清IGF-1和VEGF水平分别为(125.32±12.28)ng/ml和(187.64±30.58)pg/ml,高于对照组的(78.83±12.25)ng/ml和(118.35±30.59)pg/ml,差异有统计学意义(P<0.05)。EMs患者中不同R-AFS临床分期血清中IGF-1和VEGF水平差异有统计学意义(P<0.05),血清中VEGF、IGF-1含量与EMs的严重程度存在正相关性(P<0.05),且血清VEGF和IG-I之间呈正相关性(P<0.05)。结论 VEGF、IGF-1在EMs患者血清中呈高表达状态,且与EMs病情进展密切相关,两者可能通过协同作用促进EMs病情发展,以VEGF、IGF-1为靶点可为EMs的临床诊断与治疗提供新思路。
Objective To investigate the expression of serum insulin-like growth factor-I (IGF-1) and vascular endothelial growth factor (VEGF) in patients with endometriosis (EMs) and its relationship with the severity of the disease. Methods Sixty patients with pathologically confirmed EMs were selected as the observation group. There were 14 cases of stage Ⅰ, 16 cases of stage Ⅱ, 18 cases of stage Ⅲ, 12 cases of stage Ⅳ, and 60 cases of benign ovarian mature teratoma For the control group. Fasting venous blood was collected from both groups. Serum levels of VEGF and IGF-1 were measured by ELISA in patients and different stages of R-AFS. Results The levels of serum IGF-1 and VEGF in the observation group were (125.32 ± 12.28) ng / ml and (187.64 ± 30.58) pg / ml respectively, higher than those in the control group (78.83 ± 12.25 ng / ml and 118.35 ± 30.59) pg / ml, the difference was statistically significant (P <0.05). The levels of IGF-1 and VEGF in different stage R-AFS clinical stage serum in patients with EMs were significantly different (P <0.05). There was a positive correlation between the serum levels of VEGF and IGF-1 and the severity of EMs (P <0.05) , And there was a positive correlation between serum VEGF and IG-I (P <0.05). Conclusions VEGF and IGF-1 are highly expressed in the serum of patients with EMs and are closely related to the progression of EMs. They may promote the progression of EMs through synergistic effects. The targets of VEGF and IGF-1 may be the clinical diagnosis of EMs And treatment to provide new ideas.