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为探索抗肿瘤药对膀胱癌细胞产生的免疫抑制因子 (TDSF)对肿瘤“免疫逃逸”病理生理过程的影响 ,采用免疫生化共育实验的方法 ,取得膀胱癌细胞产生的免疫抑制因子作用于人外周血单个核细胞 (PBMC) 6h ,即可抑制白细胞介素 2 (IL 2 )产生 ,与对照组相比经统计学处理P <0 .0 1。当TDSF存在时 ,经激活的PBMC效应细胞对外源性IL 2反应显著减弱 ,表明IL 2的作用受到TDSF的抑制。植物血凝素 P(PHA P)刺激PBMC增殖 ,但TDSF使其增殖抑制。表明IL 2产生及其作用受到TDSF抑制。抗肿瘤药对TDSF的分泌有阻抑作用。
In order to explore the effect of anti-tumor drugs on the pathophysiological process of immune escape caused by bladder cancer cells, immune-biochemical co-culture experiment was used to obtain the effect of immunosuppressive factors produced by bladder cancer cells on human Peripheral blood mononuclear cells (PBMC) 6h, can inhibit the production of interleukin 2 (IL 2), compared with the control group statistically P <0. When TDSF is present, the response of exogenous IL2 to activated PBMC effector cells is significantly diminished, indicating that the effect of IL2 is inhibited by TDSF. Phytohemagglutinin P (PHA P) stimulates PBMC proliferation, but TDSF inhibits its proliferation. Indicating that IL2 production and its effects are inhibited by TDSF. Antitumor drugs can inhibit the secretion of TDSF.