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用活化的聚乙二醇（２—０—甲氧聚乙二醇—４．６—二氯１．３．５—三嗪三氨杂茶）修饰牛血清白蛋白，白蛋白与不同含量的聚乙二醇偶联后，其抗原性随修饰度的增加而减少，当牛血清白蛋白６０个氨基中的２８个被修饰后，失去与抗牛血清白蛋白抗血清的免疫反应活性。
Bovine serum albumin was modified with activated polyethylene glycol (2-0-methoxypolyethylene glycol-4.6-dichloro-1.3.5-triazine triamcinolone) albumin with varying amounts of After PEG conjugation, its antigenicity decreased with the degree of modification. When 28 of the 60 amino groups of bovine serum albumin were modified, the immunoreactivity with anti-bovine serum albumin antiserum was lost.