近十年来,青少年肥胖人群迅速扩大,随之而来的是2型糖尿病发病的年轻化,那些处于糖调节受损状态的肥胖青少年往往患有严重的胰岛素抵抗(IR) ,导致成年后较早出现高血压、血脂异常以及代谢综合征。判断胰岛素敏感性或胰岛素抵抗程度的指标包括( 1)正常血糖高胰岛素钳夹试验和( 2 Over the past decade, the adolescent obesity population has rapidly expanded, with the consequent rejuvenation of type 2 diabetes. Obese adolescents with impaired glucose regulation often have severe insulin resistance (IR), leading to earlier onset in adulthood Hypertension, dyslipidemia and metabolic syndrome occur. Indicators to determine the extent of insulin sensitivity or insulin resistance include (1) normal glucose hyperinsulinemic clamp and (2