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目的观察解毒通络调肝散对糖尿病胰岛素抵抗模型大鼠肝脏IRS-2的影响。方法采用高脂饮食加链脲佐菌素诱导糖尿病胰岛素抵抗大鼠模型。将造模成功的大鼠随机分为模型组、二甲双胍组、吡咯列酮组和解毒通络调肝组。给药8周后进行各指标检测。结果解毒通络调肝散能升高糖尿病胰岛素抵抗大鼠胰岛素敏感性指数,增加实验性糖尿病(DM)大鼠肝脏组织IRS-2的表达。结论解毒通络调肝散对大鼠IR有显著的改善作用,其机制可能与增加实验性糖尿病(DM)大鼠肝组织中IRS-2表达有关。
Objective To observe the effect of Jiedu Tongluo Tiaogan Powder on hepatic IRS-2 in model rats with diabetes mellitus insulin resistance. Methods A diabetic rat model of insulin resistance was induced by high fat diet plus streptozotocin. Rats with successful modeling were randomly divided into model group, metformin group, pirrolide group, and detoxification meridian-regulating liver group. After 8 weeks of dosing, each index was tested. Results Jiedu Tongluo Tiaogan Powder can increase the insulin sensitivity index of diabetic insulin resistance rats and increase the expression of IRS-2 in liver tissue of experimental diabetic rats. Conclusion Jiedu Tongluo Tiaogan Powder can significantly improve the IR of rats, and its mechanism may be related to the increase of IRS-2 expression in the liver of experimental diabetic rats.