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目的:探讨MHC-Ⅰ在IIM发生发展中的作用和机制。方法:对收集的15例IIM患者进行肌肉活检,观察其病理结构的改变、MHC-Ⅰ在患者肌肉组织中的分布表达情况,并与非炎症性肌病患者作对照。结果:1.在IIM患者肌肉组织中明确有MHC-Ⅰ类分子的表达,其阳性率为100%;2.虽有6例IIM患者肌纤维中没有明显的炎性细胞浸润,但患者还是出现了临床症状且肌酶异常;3.MHC-Ⅰ在IIM肌肉组织中的表达强弱程度与病人肌酶呈正相关性,且具有统计学意义(P<0.05)。结论:MHC-Ⅰ类分子可以作为IIM早期诊断的指标之一,其表达强弱与患者病情程度有相关性。
Objective: To investigate the role and mechanism of MHC-Ⅰ in the development of IIM. Methods: Fifteen patients with IIM were collected for muscle biopsy. The pathological changes of MHC-Ⅰ were observed. The distribution and distribution of MHC-Ⅰ in muscle tissue of patients were compared with those of non-inflammatory myopathy patients. The positive expression of MHC class I molecules in muscle tissue of IIM patients was 100% .2. Although there was no obvious infiltration of inflammatory cells in the muscle fibers of 6 patients with IIM, patients still appeared Clinical symptoms and abnormal muscle enzymes; 3. The expression of MHC-I in muscle tissue of IIM was positively correlated with muscle enzymes of patients with statistical significance (P <0.05). Conclusion: MHC-Ⅰ molecules can be used as one of the indicators of early diagnosis of IIM. The expression level of MHC-Ⅰ is correlated with the severity of patients.