本文复习了有关暴发性肝衰竭近十年的文献。该综合征可能由病毒、毒素(或药物)作用,加上免疫调节功期障碍所引起。氨基酸代谢失常、血脑屏障通透性增强,毒性代谢产物进入脑内造成脑病和脑水肿。机体抗感染能力(如补体活性、调理作用等)降低,易合并继发感染。肝屏障作用下降,大量内毒素进入血循环可造成肾衰。治疗上应加强监护,进行综合治疗。 This article reviews the literature on fulminant hepatic failure for nearly a decade. The syndrome may be caused by viruses, toxins (or drugs), and immune-mediated dyskinesia. Amino acid metabolism disorders, increased permeability of the blood-brain barrier, toxic metabolites into the brain cause encephalopathy and cerebral edema. Anti-infective ability of the body (such as complement activity, conditioning, etc.) to reduce, easy to merge secondary infection. The role of the liver barrier decreased, a large number of endotoxin into the blood circulation can cause renal failure. Treatment should be strengthened monitoring, comprehensive treatment.